“…Sounds traditional for a kids’ movie, but I like the twist that she’s popular, an alpha wolf, while he’s a loser/slacker type. It sounds like a mashup of a high-school comedy with a cartoon wilderness adventure…”

Sounds more like a mashup than a twist. :) Having the loser/slacker type be female for once (and having the popular alpha she hangs with be male) would be more of a twist. ;)