These comics and manga have lead characters who aren’t Sherlock Holmes or John Watson, but who are closely related. The list is arranged alphabetically.
Irene Adler leads a group of women adventurers in the steampunk-flavored Adler, written by Lavie Tidhar and illustrated by Paul McCaffrey (Titan Comics, 2021, a collection of the five-issue miniseries).
IDW published in hardcover the first three Serena Blasco adaptations (originally published in French) of Nancy Springer’s YA novels.
Major Holmes & Captain Watson, written by Jeff Rider and illustrated by Ismael Canales, stars a blond Sheffield Holmes, nephew of Sherlock and Mycroft, who goes on missions in 1914 with Captain Imogen Watson (4 issues, Cloudwrangler Comics, 2020-2021). A dynamite wartime spy adventure, punctuated by diverse lead characters — gay, female, Black — who go beyond the traditional to create a nail-biting recommended read with plenty of classic references.
Moriarty (Image Comics, 2011-2012, collected edition 2013), written by Daniel Corey, art by Anthony Diecidue and Mike Vosburg, takes a “Victorian horror movie” approach in a world without Sherlock Holmes. The aging Professor Moriarty tries to find the missing Mycroft Holmes at the dawn of World War I before getting involved in mystic adventures in Burma. The supernatural threat of a psychic box gives him a chance to change his fate, with plenty of action and fighting (and a female ninja). A very pulpy, sometimes confusing approach.
Although numbered as volume 3 of the publisher’s Sherlock Holmes series, Moriarty Lives (Dynamite, 2016, written by David Liss, art by Daniel Indro, Olavo Costa, and Carlos Furuzono, cover by Francesco Francavilla) doesn’t feature the detective at all. Instead, Moriarty pulls himself from the Reichenbach Falls and, accompanied by an orphan boy, takes on the local bully, a Baron who practices alchemy, in what eventually becomes a heist conspiracy.
Son of Sherlock Holmes (Pyramid Books, 1977, written by Byron Preiss, illustrated by Ralph Reese) has little connection to the classic detective. There’s a prologue with him unable to find a missing treasure, but the majority of the book features a modern (for the times) detective character, someone rumored to be Holmes’ son, in a European caper, chasing around after the hidden fortune.
Violet Holmes, an original character and Sherlock’s adopted daughter, appears in Violet Holmes and the Agents of H.I.V.E.: Adventures of a Teenage Detective, written by Nicko Vaughan and illustrated by Georgia Grace Weston (Orange Pip Books, 2020).
Young Miss Holmes is a manga take by Kaoru Shintani starring Sherlock’s niece Lady Christie. The series moves from retelling Doyle stories to creating its own adventures (3 volumes in English collecting 7 Japanese volumes, Seven Seas Entertainment, 2012-2013). The Japanese original was called Christie High Tension and ran 2007-2011; the four-volume sequel, Christie London Massive (2011-2017), has not been translated into English.